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Hint: The Site of a Great Tragedy Is Now a Research Center

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Welcome to Cornerspotter, Curbed's game in which you try to identify the location and/or identity of a particular building or streetscape in a historic photograph. Impress us and your fellow Curbed readers with your uncanny insight into New York City and its past!

Over the course of its 102-year history, this structure—designed by an architect known for building theaters—has been used as a dance hall, as a sanctuary for a synagogue's religious services, and as a biotech research facility. Thanks to a preservation battle to save it and a recent restoration, the facade looks pretty much the same as it did a century ago. What is the name of the building, where is it, and what notable event occurred there?
· Cornerspotter archives [Curbed]